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Medical Science Case Reports (MSCR) developed as an independent title journal in 2014 from the case reports section of Medical Science Monitor.

Aim of the Journal
MSCR is an Open Access, peer-reviewed online journal, which aims at contributions advancing health professional education and coverage of original case reports from all medical specialties. MSCR will expand medical knowledge and thus... read more

Published: 2021-06-18



Unusual Presentation of Breast Cancer: Acute Budd-Chiari Syndrome

Jacqueline Kropf, Danielle Lee, Zachary Field, Chukwuemeka Oriala, Calvin Gutierrez, Samuel Giday, Steve J. Carlan

Department of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA

Med Sci Case Rep 2021; 8:e919072

DOI: 10.12659/MSCR.919072

BACKGROUND: Budd-Chiari syndrome (BCS) is an uncommon condition caused by hepatic venous outflow obstruction. It is typically a result of a thromboembolic event but can also be caused by external venous compression. Metastatic disease to the liver can be a source of venous compression but to this point breast cancer has not been reported to cause BCS.
CASE REPORT: A 64-year-old woman presented with acute onset abdominal pain and imaging noted findings consistent with BCS. Liver biopsy revealed metastatic adenocarcinoma of the breast. She developed fulminant liver failure secondary to Budd-Chiari syndrome before chemotherapy could be started and died within 2 weeks of diagnosis.
CONCLUSIONS: Budd-Chiari syndrome can present with signs of abdominal venous congestion and hepatic failure caused by extravascular compression of hepatic veins and the inferior vena cava. Clinical manifestations range from severe abdominal pain to hepatic encephalopathy. Cases occurring secondary to mass effect should elicit suspicion of metastatic disease to the liver and prompt early intervention to prevent fulminant liver failure. BCS can be caused by metastatic breast cancer.

Keywords: Budd-Chiari syndrome, Carcinoma, Hepatocellular, GATA3 Transcription Factor

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