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Medical Science Monitor Basic Research


Short-Term Effect of Twice-Daily Dosage of Repaglinide in Elderly Patients with Type 2 Diabetes

Daisuke Takarabe, Tetsuro Tsujimoto, Miyako Kishimoto, Mitsuhiko Noda

Department of Endocrinology and Metabolism, Tama-Hokubu Medical Center, Tokyo, Japan

Med Sci Case Rep 2015; 2:53-57

DOI: 10.12659/MSCR.895993

Available online: 2015-11-09

Published: 2015-11-09


BACKGROUND: Repaglinide is typically administered 3 times daily before meals. However, treatment regimens for elderly patients should be simplified as much as possible.
CASE REPORT: We report the cases of 2 elderly patients with type 2 diabetes (T2D) admitted to the hospital for glycemic control. Using continuous glucose monitoring, we monitored the effects of a twice-daily dosage of repaglinide compared with 3-times-daily dosage in the patients. In patient 1, we observed some worsening of glycemic control during the twice-daily treatment period, compared with the effects during the 3-times-daily treatment period. However, in patient 2, we did not observe any apparent worsening of that.
CONCLUSIONS: In some patients, the twice-daily dosage of repaglinide may be useful for their glycemic control to reach target.

Keywords: Diabetes Mellitus, Type 2, Frail Elderly, medication adherence